Tumor specific transplantation antigens are unique to tumor
cells and do not occur on normal cells in the body. They may result from
mutations in tumor cells that generate altered cellular proteins; cytosolic
processing of these proteins are presented with class I MHC molecules inducing a
cell mediated response by tumor specific CTLs.
Tumor associated transplantation antigens (TATAs) are not unique
to tumor cells; may be proteins that are expressed on normal cells during fetal
development when the immune system in immature. Reactivation of the embryonic
genes that encode these proteins in tumor cells results in their expression on
the fully differentiated tumor cells.
Transformed African Green MonkeyKidney Fibroblast Cells (COS-7 Line)
